Highways

US Route 24, a major east-west highway, serves Defiance along State Routes 15, 18, 66, 111, 281.

Rail

Service is provided to Defiance by CSX Transportation (Chessie) and Indiana Hi-Rail.

Truck

Defiance is serviced by numerous trucking companies, including: American Eagle Express, Central Transport, Hornish Trucking, Tom Keller Trucking, Roadway Express, SNS Express and Yellow Freight System.

Bus

The Trailways Bus Line provides bus transportation to Defiance.

Air

Commercial flight service is available from Toledo and Fort Wayne. Toledo Express Airport has over 70 commercial flights daily on United, Delta, Connair, Peidmont, TWA, and U.S. Air. The Burlington freight terminal is available to expedite air shipments. Defiance has a Class A airport located five miles northwest of the city. It features a 4,200-foot paved and lighted runway with hangar facilities. Charter flights, pilot training, and aircraft maintenance are also available.